Mitogenic pathways regulated by G protein oncogenes.

Mitogenic signaling via G protein-coupled receptors.

The stimulation of mitogenic signaling pathways by N-POMC peptides

The N-terminal fragment of pro-opiomelancortin (POMC) has been shown previously to act as an adrenal mitogen. However, little is known about the molecular mechanisms by which mitogenesis is stimulated, although it has been shown that N-POMC(1-28) stimulates the ERK pathway in human H295R cells. We have investigated signaling stimulated by N-POMC(1-28) and N-POMC(1-49) in the mouse Y1 cell line ...

Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells.

Angiotensin II (AngII) receptors couple to a multitude of different types of G-proteins resulting in activation of numerous signaling pathways. In this study we examined the consequences of this promiscuous G-protein coupling on secretion. Chromaffin cells were voltage-clamped at -80 mV in perforated-patch configuration, and Ca(2+)-dependent exocytosis was evoked with brief voltage steps to +20...

Protein Modification: Palmitoylation in G-protein signaling pathways

The reversible palmitoylation of G proteins and their receptors is involved both in receptor desensitization and in association and disassociation of G alpha subunits with the plasma membrane.

Identifying Unfolding Pathways of G Protein-Coupled Receptor Protein Structures

G protein-coupled receptors (GPCRs) have important functionality in cell signaling processes by external affects such as light, smell, taste, and hormones. The conformational changes in structures of GPCR’s play vital role in signaling processes. The understanding of conformational changes is useful to determine basis of certain diseases that are related to malfunctioning of these proteins. The...